Area-at-risk assessed by CMR predicts improvement in LVEF and LV GLS, while myocardial salvage index predicts LV GCS recovery at 3 months post-STEMI (P=0.020).
Cohort (n=66)
Do morphological features of infarcted myocardium assessed by CMR predict left ventricular functional recovery at three months in patients with acute STEMI?
CMR-derived area-at-risk and myocardial salvage index assessed during the acute stage of STEMI can predict left ventricular functional recovery at 3 months.
p-value: p== 0.020
BACKGROUND: Left ventricular global longitudinal strain (LV GLS) is a superior predictor of adverse cardiac events in patients with myocardial infarction and heart failure. We investigated the ability of morphological features of infarcted myocardium to detect acute left ventricular (LV) dysfunction and predict LV functional recovery after three months in patients with acute ST-segment elevation myocardial infarction (STEMI). METHODS: Sixty-six STEMI patients were included in the C-reactive protein (CRP) apheresis in Acute Myocardial Infarction Study (CAMI-1). LV ejection fraction (LVEF), LV GLS, LV global circumferential strain (LV GCS), infarct size (IS), area-at-risk (AAR), and myocardial salvage index (MSI) were assessed by CMR 5 ± 3 days (baseline) and 12 ± 2 weeks after (follow-up) the diagnosis of first acute STEMI. RESULTS: = 0.020) but not in LV GCS. CONCLUSION: The CMR tissue characteristics of myocardial injury correlate with the magnitude of LV dysfunction during the acute stage of STEMI. AAR predicts improvement in LVEF and LV GLS, while MSI is a sensitive marker of LV GCS recovery at three months follow-up after STEMI.
Virbickiene et al. (Tue,) conducted a cohort in Acute ST-segment elevation myocardial infarction (STEMI) (n=66). Cardiac Magnetic Resonance (CMR) assessment was evaluated on Left ventricular functional recovery (LVEF, LV GLS, LV GCS) at three months (p== 0.020). Area-at-risk assessed by CMR predicts improvement in LVEF and LV GLS, while myocardial salvage index predicts LV GCS recovery at 3 months post-STEMI (P=0.020).