Continuous positive airway pressure (CPAP) treated supine hypertension of autonomic failure while improving nocturia and daytime orthostatic hypotension compared to placebo (P=0.014).
RCT
Does continuous positive airway pressure (CPAP) improve nocturnal supine hypertension, nocturnal diuresis, and daytime orthostatic hypotension in patients with autonomic failure?
CPAP represents a novel nonpharmacologic approach to treat supine hypertension of autonomic failure while improving nocturia and daytime orthostatic hypotension.
p-value: p=0.014
BACKGROUND: Supine hypertension affects most patients with orthostatic hypotension (OH) due to autonomic failure, but it is often untreated for fear of worsening OH. We hypothesized that increasing intrathoracic pressure with continuous positive airway pressure (CPAP) had a Valsalva-like blood-pressure-lowering effect that could be used to treat nocturnal supine hypertension in these patients, while reducing nocturnal pressure diuresis and improving daytime OH. METHODS: O for 8 hours) versus placebo on nocturnal supine hypertension, nocturnal diuresis and daytime OH in a 2-night crossover study. RESULTS: =0.014). CONCLUSIONS: CPAP is a novel nonpharmacologic approach to treat the supine hypertension of autonomic failure while improving nocturia and daytime OH. REGISTRATION: URL: https://www. CLINICALTRIALS: gov; Unique identifier: NCT03312556.
Okamoto et al. (Thu,) conducted a rct in Supine hypertension and orthostatic hypotension in autonomic failure. Continuous positive airway pressure (CPAP) vs. Placebo was evaluated on Nocturnal supine hypertension, nocturnal diuresis and daytime OH (p=0.014). Continuous positive airway pressure (CPAP) treated supine hypertension of autonomic failure while improving nocturia and daytime orthostatic hypotension compared to placebo (P=0.014).
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