September 23, 2019Open Access
View Full PaperThe Quest for Antiinflammatory and Immunomodulatory Strategies in Heart Failure
Key Result
Antiinflammatory and immunomodulatory therapies for heart failure have shown limited clinical success, highlighting the need for specific treatments that avoid nonspecific immune suppression.
Structured PICO
P
Population
Heart failure (HF)
I
Intervention
Antiinflammatory and immunomodulatory therapies
This review highlights the complexity of inflammation in heart failure and calls for targeted immunomodulatory therapies that avoid nonspecific immune suppression.
Abstract
Intensive research over the last 3 decades has unequivocally demonstrated the relevance of inflammation in heart failure (HF). Despite our current and ever increasing knowledge about inflammation, the clinical success of antiinflammatory and immunomodulatory therapies in HF is still limited. This review outlines the complexity and diversity of inflammation, its reciprocal interaction with HF, and addresses future perspectives, calling for immunomodulatory therapies that are specific for factors that activate the immune system without the risk of nonspecific immune suppression.
Cite This Study
Linthout et al. (Mon,) conducted a review in Heart failure. Antiinflammatory and immunomodulatory therapies was evaluated. Antiinflammatory and immunomodulatory therapies for heart failure have shown limited clinical success, highlighting the need for specific treatments that avoid nonspecific immune suppression.