Resolution of youth metabolic syndrome by adulthood normalized the risk of high carotid intima-media thickness and type 2 diabetes to levels similar to those who never had the syndrome (p>0.20).
Cohort (n=1,757)
Yes
Does the resolution of metabolic syndrome from youth to adulthood reduce the risk of high carotid intima-media thickness and type 2 diabetes?
Resolution of metabolic syndrome from youth to adulthood normalizes the risk of high carotid intima-media thickness and type 2 diabetes to levels seen in individuals who never had metabolic syndrome.
Effect estimate: RR 3.4 for high IMT, RR 12.2 for T2DM (persistent vs never MetS) (95% CI 2.4-4.9 for high IMT, 6.3-23.9 for T2DM)
p-value: p=>0.20
OBJECTIVES: The aim of this study was to examine the effect of resolution from metabolic syndrome (MetS) between youth and adulthood on carotid artery intima-media thickness (IMT) and type 2 diabetes mellitus (T2DM). BACKGROUND: Published findings demonstrate that youth with MetS are at increased risk of cardio-metabolic outcomes in adulthood. It is not known whether this risk is attenuated in those who resolve their MetS status. METHODS: Participants (n = 1,757) from 2 prospective cohort studies were examined as youth (when 9 to 18 years of age) and re-examined 14 to 27 years later. The presence of any 3 components (low high-density lipoprotein cholesterol, high triglycerides, high glucose, high blood pressure, or high body mass index) previously shown to predict adult outcomes defined youth MetS; the harmonized MetS criteria defined adulthood MetS. Participants were classified according to their MetS status at baseline and follow-up and examined for risk of high IMT and T2DM. RESULTS: Those with MetS in youth and adulthood were at 3.4 times the risk (95% confidence interval: 2.4 to 4.9) of high IMT and 12.2 times the risk (95% confidence interval: 6.3 to 23.9) of T2DM in adulthood compared with those that did not have MetS at either time-point, whereas those that had resolved their youth MetS status by adulthood showed similar risk to those that did not have MetS at either time-point (p > 0.20 for all comparisons). CONCLUSIONS: Although youth with MetS are at increased risk of adult high IMT and T2DM, these data indicate that the resolution of youth MetS by adulthood can go some way to normalize this risk to levels seen in those who have never had MetS.
Magnussen et al. (Wed,) conducted a cohort in Metabolic syndrome (n=1,757). Resolution of youth metabolic syndrome vs. Persistent metabolic syndrome or never having metabolic syndrome was evaluated on High carotid intima-media thickness (IMT) and type 2 diabetes mellitus (T2DM) (RR 3.4 for high IMT, RR 12.2 for T2DM (persistent vs never MetS), 95% CI 2.4-4.9 for high IMT, 6.3-23.9 for T2DM, p=>0.20). Resolution of youth metabolic syndrome by adulthood normalized the risk of high carotid intima-media thickness and type 2 diabetes to levels similar to those who never had the syndrome (p>0.20).
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