Teenage patients with schizophrenia or schizophreniform disorder had significantly larger ventricular-brain ratios compared to borderline patients and controls (p<0.0001).
Case-Control (n=41)
Do teenage patients with schizophrenia spectrum disorder have larger ventricular-brain ratios compared to controls?
Ventricular enlargement is present early in the course of schizophrenia, as evidenced by significantly larger ventricular-brain ratios in teenage patients compared to controls.
p-value: p=<0.0001
Recent research has demonstrated statistically significant differences between the ventricular-brain ratios (VBRs) of schizophrenic patients and control subjects. In this study the VBRs of teenage schizophrenic/schizophreniform patients (N = 15) and borderline patients (N = 8) were measured and compared with those of controls of similar ages (N = 18). The schizophrenic group had significantly larger ventricles than the other two groups (p less than .0001). These findings support the hypothesis of previous investigators that ventricular enlargement is present early in the course of schizophrenia.
Schulz et al. (Thu,) conducted a case-control in Schizophrenia spectrum disorder (n=41). Schizophrenia/schizophreniform diagnosis vs. Borderline patients and controls was evaluated on Ventricular-brain ratios (VBRs) (p=<0.0001). Teenage patients with schizophrenia or schizophreniform disorder had significantly larger ventricular-brain ratios compared to borderline patients and controls (p<0.0001).