Cardiovascular disease remains the leading cause of mortality in Italy, driven by a combination of population-specific genetic variants, low adherence to healthy lifestyles, and metabolic risk factors.
Understanding population-specific genetic, lifestyle, and metabolic risk factors is crucial for designing tailored cardiovascular prevention strategies in Italy.
Cardiovascular diseases (CVD) represent a major health problem worldwide. In Italy, despite the decline in CVD mortality and disability-adjusted life years recently observed, CVD remains the leading cause of death. The development of CVD has a complex and multifactorial etiology that involves environmental, lifestyle/behavioral (e.g., unhealthy diet, physical inactivity, smoking, and alcohol abuse), metabolic, and genetic factors. Although a large number of CVD susceptibility genetic variants have been identified, some seem to confer risk according to the genetic background or ethnicity of the population. Some CVD-associated polymorphisms with appreciable frequency in the Italian population may be important contributors to the development and progression of the most prevalent CVD in the population. This literature review aims to provide an overview of the epidemiology of CVD in Italy, as well as to highlight the main genetic, lifestyle/behavioral, and metabolic factors contributing to CVD risk in this population.
Ojeda‐Granados et al. (Thu,) conducted a review in Cardiovascular disease. Cardiovascular disease remains the leading cause of mortality in Italy, driven by a combination of population-specific genetic variants, low adherence to healthy lifestyles, and metabolic risk factors.
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