Beyond the Sinus Node: Heterogeneous Atrial Substrate in Atrial Fibrillation With Sick Sinus Syndrome

Key Points

• To explore the heterogeneous atrial substrate characteristics in patients with atrial fibrillation and sick sinus syndrome.
• Conducted a randomized trial with subjects diagnosed with atrial fibrillation and sick sinus syndrome.
• Utilized electrophysiological mapping to assess atrial substrate variability.
• Analyzed the relationship between substrate characteristics and arrhythmia occurrence.
• Identified significant variations in atrial substrate across the population, indicating different arrhythmogenic potentials.
• Documented that specific substrate features correlate with increased atrial fibrillation episodes.
• Found that patients with more heterogeneous substrates had a higher risk of arrhythmias.