Every 1-MET increase in cardiorespiratory fitness was associated with a reduced risk of type 2 diabetes in the general population (HR 0.90; 95% CI 0.86-0.94) and statin users.
Meta-Analysis
Does higher cardiorespiratory fitness reduce the risk of type 2 diabetes in the general population and statin users?
Higher cardiorespiratory fitness is associated with a dose-dependent reduction in type 2 diabetes risk, potentially eliminating the diabetogenic effect of statins.
Effect estimate: HR 0.90 (95% CI 0.86-0.94)
Objective This meta‐analysis aimed to (1) quantify the association of cardiorespiratory fitness (CRF) with type 2 diabetes risk in the general population and statin users and (2) investigate the joint effects of CRF and fatness with type 2 diabetes risk. Methods Databases were searched for cohort studies reporting the association between CRF and type 2 diabetes risk. Summary hazard ratios (HRs) were obtained using random‐effects models. Results Fifteen studies were included. The HRs of type 2 diabetes for every 1–metabolic equivalent increase in CRF were 0.90 (95% CI: 0.86‐0.94) for the general population and 0.92 (95% CI: 0.87‐0.97) for statin users, and the HRs were linearly shaped (both P nonlinearity > 0.40). Compared with the nonstatin cohort, there was an increased risk of type 2 diabetes in statin users with the lowest and moderate CRF categories, but this was not present in the highest CRF category. The HR of type 2 diabetes for overweight/obesity‐fit category versus normal weight–fit category was larger than that of the normal weight–unfit category versus the normal weight–fit category ( P interaction = 0.004). Conclusions There was an inverse and dose‐dependent association between CRF and type 2 diabetes risk. High CRF may eliminate the diabetogenic effect from statins, yet decreased body weight index seems superior in preventing type 2 diabetes.
Qiu et al. (Thu,) conducted a meta-analysis in Type 2 diabetes. Cardiorespiratory fitness (CRF) was evaluated on Type 2 diabetes risk (HR 0.90, 95% CI 0.86-0.94). Every 1-MET increase in cardiorespiratory fitness was associated with a reduced risk of type 2 diabetes in the general population (HR 0.90; 95% CI 0.86-0.94) and statin users.