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There are many important attributes of the enzyme glucose-6-phosphate dehydrogenase (G-6-PD) which make it an exceedingly attractive system for genetic analysis in man: Much is known about the physiologic function of the enzyme; it is present in many tissues of the body; and its activity can be quantitatively measured. Furthermore, mutations are known which either alter the enzyme in a qualitative manner or appear to alter it in a quantitative way, or both. Several of these mutations are quite common in certain populations. Finally, at least one genetic determinant of the enzyme is located on the X-chromosome, and this gene is expressed at a cellular level in undifferentiated tissue culture cells. These useful properties of the G-6-PD system have been utilized to perform linkage studies with other sex-linked genes (Porter, Schulze, and McKusick, 1962; Adam, Sheba, Race, Tippett, Hamper, Gavin, and Finney, 1963; Siniscalco, Motulsky, Latte, and Bernini, 1960), to...
W E Nance (Wed,) studied this question.