Atrial fibrillation was significantly associated with an increased risk of major arrhythmic events in patients with Brugada syndrome (OR 2.37; 95% CI 1.36–4.13; p=0.002).
Meta-Analysis (n=1,703)
Does previous documented atrial fibrillation increase the risk of major arrhythmic events in patients with Brugada syndrome?
In patients with Brugada syndrome, a history of atrial fibrillation is associated with a more than twofold increased risk of major ventricular arrhythmic events.
Effect estimate: OR 2.37 (95% CI 1.36–4.13)
p-value: p=0.002
Abstract Background Brugada syndrome (BrS) is a common cause of sudden cardiac death (SCD). There is recent evidence that atrial fibrillation (AF) is associated with increased risk of SCD in general population. However, whether AF increases a risk of major arrhythmic events (MAE) in patients with BrS is still unclear. We performed a systematic review and meta‐analysis to explore the effect of AF on MAE in BrS population. Methods We searched the databases of MEDLINE and EMBASE from inception to March 2019. Included studies were published cohort studies reporting rates of MAE (ventricular fibrillation, sustained ventricular tachycardia, SCD, or sudden cardiac arrest) in BrS patients, with and without previous documented AF. Data from each study were combined using the random‐effects model. Results Six studies from 1,703 patients were included. There was a significant association between AF and an increased risk of MAE in patients with BrS (pooled OR = 2.37, 95% CI = 1.36–4.13, p ‐value = .002, I 2 = 40.3%). Conclusions Our meta‐analysis demonstrated that AF is associated with an increased risk of MAE in patients with BrS.
Kewcharoen et al. (Mon,) conducted a meta-analysis in Brugada syndrome (n=1,703). Atrial fibrillation vs. Without previous documented atrial fibrillation was evaluated on Major arrhythmic events (ventricular fibrillation, sustained ventricular tachycardia, sudden cardiac death, or sudden cardiac arrest) (OR 2.37, 95% CI 1.36–4.13, p=0.002). Atrial fibrillation was significantly associated with an increased risk of major arrhythmic events in patients with Brugada syndrome (OR 2.37; 95% CI 1.36–4.13; p=0.002).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: