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This research explores the duration and effectiveness of translating scientific evidence into clinical practice, specifically for lipid emulsion therapy in local anesthetic systemic toxicity.

May 20, 2026

Rapid translation of scientific knowledge into clinical practice: the example of lipid emulsion therapy for local anesthetic systemic toxicity

Key Points

This research explores the duration and effectiveness of translating scientific evidence into clinical practice, specifically for lipid emulsion therapy in local anesthetic systemic toxicity.
Analysis of translational gaps in medical evidence and practice
Evaluation of lipid emulsion therapy in relation to clinical applications
Comparison of timelines for evidence publication versus practice implementation
Identification of a 17-year gap in the translation of evidence into clinical use
Significant delays noted particularly in the field of anesthesiology
Recommendations made for enhanced communication strategies to bridge the gap

Abstract

Delays between publication of evidence and implementation in routine practice are often substantial. A ‘17-year gap’ is frequently cited in translational medicine, although estimates vary by field and methodology.11 More recent analyses also suggest that incorporation of evidence into

Rapid translation of scientific knowledge into clinical practice: the example of lipid emulsion therapy for local anesthetic systemic toxicity

Key Points

Abstract

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