Abstract Inborn errors of immunity are a heterogeneous group of diseases characterized by a deficiency in the function of the immune system, which leads to the involvement of various organs and systems, including the respiratory system. Methodology This study analyzed the respiratory manifestations in patients with predominantly antibody deficiencies at the Fundación Hospital de la Misericordia between 2021 and 2025. We gathered demographic variables, as well as clinical characteristics including the presence of allergic comorbidities, respiratory functional alterations, immunological and radiological findings. Results In our cohort a total of 72 patients were found to have humoral or predominant antibody deficiencies. Of these, 42 were men and 30 were women, with age at diagnosis of 70 months. The frequent diagnoses were: SAD in 32 patients (44.4%), selective IgA deficiency in 12 (16.7%), CVID in 12 (16.7%), ALX in 7 patients (9.7%) and HTI in 4 (5.6%). Chest CT scans were performed on 44% of the patients. Of these, 8 had atelectasis (25%), 6 had bronchiectasis (18.8%), 3 had ground-glass opacities (9.3%), 2 had mosaic attenuation (6.3%), and 1 had consolidation (3.1%). Of the 7 patients diagnosed with bronchiectasis, 3 had a diagnosis of X-linked agammaglobulinemia, and 4 had a diagnosis of SAD. The frequency of bronchiectasis in the X-linked group was 3/7 (42.9%) versus the specific antibody deficiency group (4/32, 12.5%). None of the patients with other antibody deficiencies had bronchiectasis. Of the 72 patients, 45 had a diagnosis of asthma, of whom 13 were classified as having severe asthma. Total IgE levels were elevated in 44.4% (n = 32) of cases. Skin prick testing was performed in 21 patients, revealing sensitization in 18% (n = 13), all of whom were sensitized to house dust mites. The condition with the highest rate of allergen sensitization was SAD. A significant association was found between the presence of severe asthma and elevated IgE levels. Conclusion The presence of allergen sensitization in patients diagnosed with asthma does not exclude the possibility of an inborn error of immunity, as there are milder phenotypes—such as specific polysaccharide antibody deficiency—that, due to their less severe nature, may coexist with allergic asthma. This abstract is funded by: NONE
Artunduaga et al. (Fri,) studied this question.