B54-12 Alpha-Blockers Use for Benign Prostate Hypertrophy Is Not Associated With Higher Mortality Rate in Hospitalized Male Patients With Cardiac Arrest

Abstract Alpha 1-adrenergic receptor blocking agents (α1-blockers), such as tamsulosin and doxazosin, are commonly used to treat benign prostate hyperplasia by inhibiting smooth muscle constriction at the bladder outlet. These agents are also used to treat resistant arterial hypertension as they induce arterial vasodilation, thereby decreasing systemic vascular resistance. Recent reports suggest that ABs may be associated with higher risk of adverse cardiovascular outcomes, including hospitalization for stroke or heart failure, MI, or death compared with 5-alphareductase inhibitors. However, there is limited data on the effect of α1-blockers and cardiac arrest outcomes among hospitalized patients. We aimed to investigate whether there is any association between alpha-adrenergic antagonists and mortality rate among hospitalized patients who suffered from a cardiac arrest. Alpha blockers may oppose the alpha agonist effects of epinephrine, which is the primary medication that induces vasoconstriction and increases cardiac output during cardiopulmonary resuscitation. Therefore, we hypothesized that in a cardiac arrest, male patients taking alpha blockers would have a higher mortality rate. In this study, we conducted a retrospective analysis of 192 hospitalized male patients (62% were African American, 56% were Caucasian, 2% were Hispanic, and 5% were unknown) who suffered a cardiac arrest between 2017 to 2020 at a tertiary referral hospital in Memphis, TN. Female patients were excluded from our study as they do not take medications for benign prostate hyperplasia (BPH). Our data were analyzed using logistic regression and adjusted for age, BMI, and race. Our results from logistic regression analysis showed that there was no significant association between taking alpha blockers and mortality among the hospitalized male patients who suffered from cardiac arrest after adjusting for age, BMI, and race (Table 1). This suggests that there might not be an antagonistic effect between the alpha blockers used in BPH with the alpha agonist effect in epinephrine when administered during a cardiac arrest. However, due to the limited number of patients included in our analysis, further study is needed to elucidate the effects of alpha blockers in cardiopulmonary resuscitation. This abstract is funded by: None