B80-4-23 Outcomes From Simultaneous Percutaneous Biopsy and Cryoablation for Highly Suspected Malignant Pulmonary Nodule

Abstract Objective To evaluate feasibility, safety and efficacy of combined biopsy and cryoablation of highly suspicious solitary pulmonary nodule. Methods From July 2020 to to July 2023, 45 patients with single highly suspected malignant pulmonary nodule underwent combined biopsy and cryoablation. Inclusion criteria : severe emphysema (FEV 30-49%), at least moderate FDG uptake SUV5, nodule size between 1-2cm and medically inoperable status. Technical success, procedural complications, diagnostic yield and local control were evaluated on retrospective analysis. Results The diagnostic yield of the biopsy specimen was 93.3%. (42/45). In the diagnostic yield, 95.2% of the pathology specimen were consistent with malignancy (60% lung adenocarcinoma, 40% squamous cell carcinoma), 4.8% reported atypical cells. Technical success were achieved in 100% of the cases. The most common complications included pneumothorax 17.8% , intrapulmonary hemorrhage 13.3% , hemoptysis 6.6% , and pleural effusion 4.4 . The 2 year local control was 87.5%. Conclusion The simultaneous diagnostic and therapeutic approach including CT-guided biopsy followed immediately by cryoablation of highly suspicious solitary pulmonary lesion based on severity of emphysema and PET FDG avidity is a safe and effective procedure with high pathologic positive yield and overall good local tumor control. This abstract is funded by: none