Abstract Introduction Streptococcal bacteremia associated with pneumonia represents a critical cause of sepsis-related mortality worldwide. Early recognition of organ dysfunction is essential for guiding management and predicting outcomes. The Sequential Organ Failure Assessment (SOFA) score quantifies multi-organ dysfunction, while serum lactate reflects systemic hypoperfusion and metabolic distress. Although both parameters are widely used, their combined predictive power and interaction within specific subpopulations remain incompletely defined. This study aimed to characterize the demographic profile of patients with Streptococcal bacteremia in a minority low-income population and evaluate the relationships among SOFA score, lactic acid, and mortality. Findings were compared with the results of Iftikhar 0.001). Mortality status explained 56% of the variance in lactate values (R² = 0.56). Neither HIV nor IVDU independently predicted SOFA or mortality, likely to reflect limited sample power. Conclusions SOFA score and serum lactate represent complementary, independent predictors of mortality in Streptococcal bacteremia with pneumonia. Elevated SOFA reflects multi-organ dysfunction, whereas lactate signifies tissue hypoperfusion; their concurrent rise identifies patients at highest mortality risk. The strong SOFA-mortality correlation aligns with the findings of Iftikhar 4 mmol/L should trigger aggressive resuscitation and ICU evaluation to improve survival outcomes. This abstract is funded by: None
Martinez et al. (Fri,) studied this question.