Resveratrol supplementation at 50 mg/kg/day significantly improved cardiac function and ameliorated left ventricular fibrosis in rats with acute myocardial infarction.
Does resveratrol improve cardiac function and reduce left ventricular fibrosis in a rat model of acute myocardial infarction?
In a rat model of myocardial infarction, resveratrol improved cardiac function and attenuated left ventricular fibrosis by inhibiting NLRP3 inflammasome activity and the TGF-β1/SMAD2 signaling pathway.
p-value: p=<0.05
Background Several studies have shown that resveratrol (RES), a naturally occurring polyphenol found in many plants, is beneficial for preventing cardiovascular diseases. However, the mechanism underlying the RES-mediated protection against myocardial infarction has not yet been revealed entirely. In this study, we investigated the protective effects of RES on cardiac function in a rat model of acute myocardial infarction (AMI) and the related underlying mechanisms. Methods Male Sprague-Dawley rats were randomly divided into four groups: Sham (sham operation), Sham-RES, AMI (AMI induction), and AMI-RES. The rat AMI model was established by the permanent ligation of left anterior descending coronary artery method. The rats in the RES-treated groups were gavaged with RES (50 mg/kg/day) daily for 45 days after the Sham operation or AMI induction; rats in the Sham and AMI groups were gavaged with deionized water. Cardiac function was evaluated by echocardiography. Atrial interstitial fibrosis was assessed by hematoxylin-eosin or Masson’s trichrome staining. Real-time PCR and western blotting analyses were performed to examine the levels of signaling pathway components. Results RES supplementation decreased the inflammatory cytokine levels, improved the cardiac function, and ameliorated atrial interstitial fibrosis in the rats with AMI. Furthermore, RES supplementation inhibited NLRP3 inflammasome activity, decreased the TGF- β 1 production, and downregulated the p-SMAD2/SMAD2 expression in the heart. Conclusion RES shows notable cardioprotective effects in a rat model of AMI; the possible mechanisms underlying these effects may involve the improvement of cardiac function and atrial interstitial fibrosis via the RES-mediated suppression of NLRP3 inflammasome activity and inhibition of the TGF- β 1/SMAD2 signaling pathway in the heart.
Jiang et al. (Fri,) conducted a other in Acute myocardial infarction (n=40). Resveratrol vs. Deionized water was evaluated on Cardiac function (LVESD, LVEDD, FS, EF) (p=<0.05). Resveratrol supplementation at 50 mg/kg/day significantly improved cardiac function and ameliorated left ventricular fibrosis in rats with acute myocardial infarction.