A simple theoretical model accurately predicts T-wave morphology in normal tissue and explains the relationship between repolarization timing and the steepest upstroke of the unipolar electrogram.
A simple theoretical model accurately predicts T-wave morphology in unipolar electrograms, clarifying the relationship between UEG upstroke and local repolarization.
Local unipolar electrograms (UEGs) permit assessment of local activation and repolarization times at multiple sites simultaneously. However, UEG-based indexes of local repolarization are still debated, in particular for positive T waves. Previous experimental and computer modeling studies have not been able to terminate the debate. In this study we validate a simple theoretical model of the UEG and use it to explain how repolarization statistics in the UEG relate to those in the action potential. The model reconstructs the UEG by taking the difference between an inverted local action potential and a position-independent remote signal. In normal tissue, this extremely simple model predicts T-wave morphology with surprising accuracy while explaining in a readily understandable way why the instant of repolarization is always related to the steepest upstroke of the UEG, both in positive and negative T waves, and why positive T waves are related to early repolarizing sites, whereas negative T waves are related to late repolarizing sites.
Potse et al. (Fri,) conducted a other in T wave morphology in unipolar electrograms. Simple theoretical model of the unipolar electrogram was evaluated on Prediction of T-wave morphology and explanation of repolarization statistics. A simple theoretical model accurately predicts T-wave morphology in normal tissue and explains the relationship between repolarization timing and the steepest upstroke of the unipolar electrogram.
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