Pre-gestational diabetes mellitus was significantly correlated with the occurrence of congenital heart defects in neonates, whereas maternal BMI showed no statistically significant association.
Cohort (n=673)
Yes
Does maternal pregestational diabetes, gestational diabetes, or BMI impact the occurrence of congenital heart defects in neonates?
Maternal pre-gestational diabetes is significantly associated with the occurrence of congenital heart defects in neonates in Puerto Rico, highlighting the importance of managing maternal diabetes.
Background: Given the pervasive issues of obesity and diabetes both in Puerto Rico and the broader United States, there is a compelling need to investigate the intricate interplay among BMI, pregestational, and gestational maternal diabetes, and their potential impact on the occurrence of congenital heart defects (CHD) during neonatal development. Methods: Using the comprehensive System of Vigilance and Surveillance of Congenital Defects in Puerto Rico, we conducted a focused analysis on neonates diagnosed with CHD between 2016 and 2020. Our assessment encompassed a range of variables, including maternal age, gestational age, BMI, pregestational diabetes, gestational diabetes, hypertension, history of abortion, and presence of preeclampsia. Results: A cohort of 673 patients was included in our study. The average maternal age was 26 years, within a range of 22 to 32 years. The mean gestational age measured 39 weeks, with a median span of 38 to 39 weeks. Of the 673 patients, 274 (41%) mothers gave birth to neonates diagnosed with CHD. Within this group, 22 cases were linked to pre-gestational diabetes, while 202 were not; 20 instances were associated with gestational diabetes, compared to 200 without; and 148 cases exhibited an overweight or obese BMI, whereas 126 displayed a normal BMI. Conclusion: We identified a statistically significant correlation between pre-gestational diabetes mellitus and the occurrence of CHD. However, our analysis did not show a statistically significant association between maternal BMI and the likelihood of CHD. These results may aid in developing effective strategies to prevent and manage CHD in neonates.
Delgado et al. (Mon,) conducted a cohort in Congenital heart defects (CHD) (n=673). Pre-gestational diabetes, gestational diabetes, and maternal BMI vs. Absence of diabetes and normal BMI was evaluated on Occurrence of congenital heart defects (CHD). Pre-gestational diabetes mellitus was significantly correlated with the occurrence of congenital heart defects in neonates, whereas maternal BMI showed no statistically significant association.