Per cent change in NT-proBNP at week 2 added independent prognostic information for cardiovascular death or HF hospitalization (HR 0.982; 95% CI 0.972-0.992; P<0.001).
Observational (n=71)
Blinded
Does serial NT-proBNP monitoring improve prognostic prediction compared to clinical disease severity scores in outpatients with destabilized heart failure?
Serial monitoring of NT-proBNP provides superior prognostic information compared to clinical assessment alone in outpatients with recently destabilized heart failure.
Effect estimate: HR 0.982 (95% CI 0.972-0.992)
p-value: p=<0.001
AIMS: To study the relative prognostic value of N-terminal pro-B-type natriuretic peptide (NT-proBNP) monitoring in addition to clinical disease severity scores (CDSSs) in outpatients with destabilized heart failure (HF). METHODS AND RESULTS: Seventy-one outpatients with recently destabilized HF were recruited. At baseline, and at all following visits, a CDSS based on Framingham criteria was obtained, and NT-proBNP levels were measured in a blind fashion. CDSS did not correlate with NT-proBNP levels at any time (P > 0.1), although their relative changes correlated during follow-up (P 0.1 for all visits), whereas changes in NT-proBNP levels were predictive at several time points: week 2 (P = 0.005), week 3 (P = 0.037), week 4 (P = 0.015), and 6 months (P = 0.026). A change in NT-proBNP levels at follow-up week 2 (%) added independent prognostic information (P < 0.001, HR 0.982, 95% CI 0.972-0.992) to baseline CDSS (P = 0.002, HR 2.05, 95% CI 1.290-3.266), age (P = 0.007, HR 1.034, 95% CI 1.009-1.059), and left ventricular ejection fraction (P = 0.013, HR 0.942, 95% CI 0.898-0.987). CONCLUSION: Serial monitoring for per cent change in NT-proBNP concentrations offers superior prognostic information to clinical assessment among outpatients with recent destabilized HF.
Pascual‐Figal et al. (Sat,) conducted a observational in Destabilized heart failure (n=71). NT-proBNP monitoring vs. Clinical disease severity scores (CDSS) was evaluated on Cardiovascular death and/or HF hospitalization (HR 0.982, 95% CI 0.972-0.992, p=<0.001). Per cent change in NT-proBNP at week 2 added independent prognostic information for cardiovascular death or HF hospitalization (HR 0.982; 95% CI 0.972-0.992; P<0.001).
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