Triglyceride high-density cholesterol-glucose body index (TyHGB index), a novel calculation combining triglyceride to high-density lipoprotein ratio (TG/HDL ratio), body mass index (BMI), and fasting plasma glucose (FPG), has been identified as a reliable predictor for the risk of metabolic diseases. Nevertheless, its relevance in the context of testosterone deficiency (TD) remains unexplored. Therefore, this study seeks to explore the association between the prevalence of TD and the TyHGB index in male patients with type 2 diabetes mellitus (T2DM). In this cross-sectional study, 1059 male patients with T2DM admitted to the hospital from 2019 to 2022 were evaluated. The study explored the association between TyHGB index and the prevalence of TD, as well as testosterone level, utilizing multivariable logistic and linear regression analyses. According to the multivariate regression analysis, the TyHGB index had a significant positive association with the prevalence of TD (per 1-SD increase, OR = 1.37, 95% CI 1.10–1.70) and a significant negative association with total testosterone (per 1-SD increase, β = −0.28, 95% CI −0.42– −0.14). The subgroup analyses show that this association was pronounced in patients without hyperlipidemia. According to the RCS analysis, an inverted-L shaped association between the TyHGB index and the prevalence of TD (inflection point at 12.6) and an L-shaped association between the TyHGB index and testosterone level (inflection point at 10.3) were observed. Additionally, AUC for TyHGB (AUC = 0.666, 95% CI 0.631–0.701) was significantly higher than those of the triglyceride-glucose index (TyG), TG/HDL ratio, BMI, FPG, and the homeostatic model assessment for insulin resistance (HOMA-IR). The study indicates that a higher TyHGB index is linked to lower testosterone levels and an increased prevalence of TD in male patients with T2DM.
Li et al. (Tue,) studied this question.