What question did this study set out to answer?

This study aims to assess the coherence-collapse structures among various biological computational models using dimensionless coupling formulations.

May 22, 2026Open Access

Dimensionless Coupling Thresholds in Biological Coherence Collapse: A Comparative Analysis of TCI, FCI, PCI, and CFTR-Informed Propagation Models

Key Points

This study aims to assess the coherence-collapse structures among various biological computational models using dimensionless coupling formulations.
Evaluated five dimensionless groups across four biological computational models.
Assessed logistic phase boundaries for robustness within each system.
Analyzed cross-system coherence collapse using R² metrics.
Logistic phase boundaries were robust across individual systems.
Cross-system coherence collapse was partial with R² = 0.523.
One dimensionless formulation failed catastrophically in CFTR biology without recalibration.

Abstract

This comparative study evaluates whether multiple independently developed biological computational twins — tissue regeneration (TCI), hair follicle synchronization (FCI), scorpion sensory degradation (PCI), and a CFTR-informed ion-channel model — exhibit shared coherence-collapse structure when expressed through dimensionless coupling formulations. Five candidate dimensionless groups are tested. Within each system, logistic phase boundaries are robust; cross-system collapse is partial (R² = 0.523). One formulation (Π₁) fails catastrophically, and absolute threshold transfer into CFTR biology fails without recalibration, correctly ranking severity but not clinical collapse points. The work introduces a falsifiable comparative architecture for studying propagation failure and recoverability across biological systems, and provides a missing second-order layer for DNA foundation models.

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