January 19, 2021
View Full PaperBlood pressure control and progression of arteriosclerosis in hypertension
Key Result
Persistent hypertension was associated with a higher annual increase in brachial-ankle pulse wave velocity compared to sustained normal blood pressure (17.32 cm/s; 95% CI 9.7-24.9; P<0.001).
Study Design
Type
Cohort (n=6,552)
Structured PICO
Does blood pressure control reduce the progression of arteriosclerosis (measured by baPWV) in patients with hypertension?
P
Population
6552 participants with hypertension from the community-based longitudinal Kailuan study, 75.37% men.
I
Intervention
Blood pressure control (achieving normal BP at follow-up)
C
Comparator
Uncontrolled blood pressure (remaining hypertensive at follow-up)
O
Outcome
Annual brachial-ankle pulse wave velocity (baPWV) increasesurrogate
Lowering blood pressure to normal levels is associated with a reduced increase in brachial-ankle pulse wave velocity, suggesting delayed progression of arteriosclerosis.
Main Result
Effect estimate: 17.32 cm/s difference (95% CI 9.7-24.9)
p-value: p=<0.001
Abstract
OBJECTIVE: Using the brachial--ankle pulse wave velocity (baPWV) as a biomarker for arteriosclerosis, we studied the effect of blood pressure (BP) and BP control on arteriosclerosis progression. METHODS AND RESULTS: The community-based longitudinal Kailuan study included 6552 participants 4938 (75.37%) men with a mean follow-up of 4.62 ± 2.21 years. Hypertension was defined based on the Joint National Committee (JNC7) criteria and the 2017 American College of Cardiology (ACC)/American Heart Association (AHA) guidelines. All study participants had hypertension and were stratified as follows according to BP at baseline and follow-up: the normal--normal normal BP (under therapy) at baseline and final follow-up, normal--hypertensive, hypertensive--normal, and hypertensive--hypertensive groups. Using the JNC7-based hypertension definition, the annual baPWV increase was the highest (P < 0.001) in the hypertensive--hypertensive group 17.32 cm/s; 95% confidence interval [CI:9.7--24.9], followed by the normal--hypertensive group (14.44 cm/s; 95% CI:5.5--23.4), and the hypertensive--normal group (0.88 cm/s; 95% CI: -7.84 to 9.60), with the normal--normal group as the reference group in a multivariable model. The model additionally included parameters, such as age, baseline baPWV, heart rate, BMI, serum glucose concentration, prevalence of antihypertensive treatment and alcohol consumption, heart rate, and estimated glomerular filtration rate. Applying the ACC/AHA guidelines and the same multivariable model, the annual baPWV increase was the highest (P < 0.001) in the hypertensive--hypertensive group (43.54 cm/s; 95% CI: 22.54--64.55), followed by the normal--hypertensive group (34.01 cm/s; 95% CI: 10.39--57.62) and the hypertensive--normal group (24.12 cm/s; 95% CI: 1.24--47.00). CONCLUSION: Lower BP and medical reduction in increased BP were associated with a reduction in the baPWV increase and may delay the progression of arteriosclerosis in hypertensive patients.
Cite This Study
Huang et al. (Tue,) conducted a cohort in Hypertension (n=6,552). Blood pressure control vs. Uncontrolled blood pressure (hypertensive-hypertensive) was evaluated on Annual brachial-ankle pulse wave velocity (baPWV) increase (17.32 cm/s difference, 95% CI 9.7-24.9, p=<0.001). Persistent hypertension was associated with a higher annual increase in brachial-ankle pulse wave velocity compared to sustained normal blood pressure (17.32 cm/s; 95% CI 9.7-24.9; P<0.001).