Vasopressin Provocation of Ventricular Dysrhythmia

Brief Reports1 February 1980Vasopressin Provocation of Ventricular DysrhythmiaKEVIN J. KELLY, M. D. , JOHN M. STANG, M. D. , HAGOP S. MEKHJIANKEVIN J. KELLY, M. D. , JOHN M. STANG, M. D. , HAGOP S. MEKHJIANAuthor, Article, and Disclosure Informationhttps: //doi. org/10. 7326/0003-4819-92-2-205 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe cardiovascular effects of vasopressin in humas were first reported in 1947 (1). Since then, cardiovascular accidents including transient ischemia, transmural myocardial injury without infarction, and actual myocardial infarction have been described (2-4). Ventricular fibrillation has followed prolonged intra-arterial infusion (5). This paper describes ventricular dysrhythmia after intravenous (i. v. ) vasopressin using the "bolus dose" technique in a patient without known heart disease. A 48-year-old woman was admitted to The Ohio State University Hospitals with hematemesis. Previously she had been admitted for recurrent alcoholic hepatitis and biopsy-proven cirrhosis. Following excess alcohol consumption, she developed dark brown emesis. She had no history. . . References1. RUSKIN A. Pitressin test of coronary insufficiency. Am Heart J 1947;34: 569-79. CrossrefMedlineGoogle Scholar2. MILLSBURCHELLPARKERKIRKLIN MHRB. Myocardial infarction and sudden death following the administration of Pitressin; additional electrocardiographic study of 100 patients given Pitressin for cholecystography. Proc Staff Meet Mayo Clin. 1949;24: 254-8. MedlineGoogle Scholar3. SLOTNIKTEIGLAND IJ. Cardiac accidents following vasopressin injection (Pitressin©). JAMA. 1951;146: 1126-9. CrossrefGoogle Scholar4. BELLERTREVINOURBAN BAE. Pitressin-induced myocardial injury and depression in a young woman. Am J Med. 1971;51: 675-9. CrossrefMedlineGoogle Scholar5. CONNRAMSBYSTORER HGE. Selective intraarterial vasopressin in the treatment of upper gastrointestinal hemorrhage. Gastroenterology. 1972;63: 634-45. CrossrefMedlineGoogle Scholar6. SIRINEKTHOMFORDPACE KNW. Adverse cardiodynamic effects of vasopressin not avoided by selective intraarterial administration. Surgery. 1977;81: 723-8. MedlineGoogle Scholar7. NOLASCO J. The effects of vasopressin on the systolic time intervals in the dog. Cardiology. 1976;61: 353-9. CrossrefGoogle Scholar8. BARRLAKINRÖSCH JRJ. Similarity of arterial and intravenous vasopressin on portal and systemic hemodynamics. Gastroenterology. 1975;69: 13-9. CrossrefMedlineGoogle Scholar9. SIRINEKTHOMFORD KN. Isoproterenol in offsetting adverse effects of vasopressin in cirrhotic patients. Am J Surg. 1975;129: 130-6. CrossrefMedlineGoogle Scholar10. VOSMIKJEDLICKAMULDERCORT JKJJ. Action of the triglycyl hormonogen of vasopressin (glypressin) in patients with liver cirrhosis and bleeding esophageal varices. Gastroenterology. 1977;72: 605-9. 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Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited BySummary of Torsades de Pointes (TdP) Reports Associated with Intravenous Drug Formulations Containing the Preservative ChlorobutanolReview of Vasopressin Use in Gynecologic SurgeryCardiomyopathie cirrhotique: une entité spécifiqueEfficacy and safety of terlipressin in cirrhotic patients with variceal bleeding or hepatorenal syndromeTerlipressin-induced ventricular arrhythmiaTorsade de Pointes Due to Noncardiac DrugsQT interval in patients with non-cirrhotic portal hypertension and in cirrhotic patients treated with transjugular intrahepatic porto-systemic shuntEffect of YM471, a nonpeptide AVP receptor antagonist, on human coronary artery smooth muscle cellsDrug Interactions with CisaprideEffects of SR 49059, a New Orally Active and Specific Vasopressin V 1 Receptor Antagonist, on Vasopressin-Induced Vasoconstriction in HumansPulmonary edema: a complication of local injection of vasopressin at laparoscopyEffects of SR 49059, a non-peptide antagonist of vasopressin V 1a receptors, on vasopressin-induced coronary vasoconstriction in conscious rabbitsDrug Information Analysis ServicePerivascular Peptides in the Coronary Circulation: Relation to PathophysiologyAltered effects of vasopressin on the coronary circulation after ischemiaPHARMACOLOGIC TREATMENT OF PORTAL HYPERTENSIONNeurohumoral and Pharmacologic Regulation of Collateral PerfusionNeurohumoral Regulation of Coronary Collateral Vasomotor ToneAttenuation of vasopressin-mediated coronary constriction and myocardial depression in the hypoxic heart. 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D. 1 February 1980Volume 92, Issue 2Part₁Page: 205-206KeywordsAlcohol consumptionAlcoholicsCardiovascular therapyCirrhosisHepatitisInfarctionIschemiaMyocardial infarctionVasopressinVentricular fibrillation Issue Published: 1 February 1980 PDF DownloadLoading. . .