Bariatric surgery significantly increased median hepatic mitochondrial DNA/nuclear DNA content by 32% and enhanced hepatic oxidative phosphorylation capacity 12 months post-surgery compared to baseline.
Observational (n=71)
No
Does bariatric surgery improve hepatic and adipose tissue mitochondrial biogenesis and respiration in patients with obesity and NAFLD?
Bariatric surgery increases hepatic mitochondrial oxidative phosphorylation and biogenesis in patients with obesity, while obesity itself is associated with reduced adipose tissue respiration independent of NAFLD severity.
Absolute Event Rate: 660% vs 481%
p-value: p=0.012
Impaired mitochondrial oxidative phosphorylation (OXPHOS) in liver tissue has been hypothesised to contribute to the development of nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease (NAFLD). It is unknown whether OXPHOS capacities in human visceral (VAT) and subcutaneous adipose tissue (SAT) associate with NAFLD severity and how hepatic OXPHOS responds to improvement in NAFLD. In biopsies sampled from 62 patients with obesity undergoing bariatric surgery and nine control subjects without obesity we demonstrate that OXPHOS is reduced in VAT and SAT while increased in the liver in patients with obesity when compared with control subjects without obesity, but this was independent of NAFLD severity. In repeat liver biopsy sampling in 21 patients with obesity 12 months after bariatric surgery we found increased hepatic OXPHOS capacity and mitochondrial DNA/nuclear DNA content compared with baseline. In this work we show that obesity has an opposing association with mitochondrial respiration in adipose- and liver tissue with no overall association with NAFLD severity, however, bariatric surgery increases hepatic OXPHOS and mitochondrial biogenesis.
Pedersen et al. (Wed,) conducted a observational in Non-alcoholic fatty liver disease (NAFLD) and obesity (n=71). Bariatric surgery (Roux-en-Y gastric bypass or sleeve gastrectomy) vs. Baseline (pre-surgery) was evaluated on Hepatic mitochondrial DNA/nuclear DNA (mtDNA/nDNA) content (p=0.012). Bariatric surgery significantly increased median hepatic mitochondrial DNA/nuclear DNA content by 32% and enhanced hepatic oxidative phosphorylation capacity 12 months post-surgery compared to baseline.