Pre-admission depression increased the risk of all-cause mortality following myocardial infarction by 11% compared to patients without previous depression (MRR 1.11).
Cohort (n=170,771)
Yes
Does a history of depression increase all-cause mortality in patients following a first-time myocardial infarction?
A history of depression prior to a first-time myocardial infarction is associated with a moderately increased risk of long-term all-cause mortality.
Effect estimate: MRR 1.11 (95% CI 1.07-1.15)
Absolute Event Rate: 87% vs 78%
Background The prognostic impact of previous depression on myocardial infarction survival remains poorly understood. Aims To examine the association between depression and all-cause mortality following myocardial infarction. Method Using Danish medical registries, we conducted a nationwide population-based cohort study. We included all patients with first-time myocardial infarction (1995–2014) and identified previous depression as either a depression diagnosis or use of antidepressants. We used Cox regression to compute adjusted mortality rate ratios (aMRRs) with 95% confidence intervals. Results We identified 170 771 patients with first-time myocardial infarction. Patients with myocardial infarction and a previous depression diagnosis had higher 19-year mortality risks (87% v. 78%). The overall aMRR was 1.11 (95% CI 1.07–1.15) increasing to 1.22 (95% CI 1.17–1.27) when including use of antidepressants in the depression definition. Conclusions A history of depression was associated with a moderately increased all-cause mortality following myocardial infarction.
Sundbøll et al. (Fri,) conducted a cohort in First-time myocardial infarction (n=170,771). Pre-admission depression vs. No pre-admission depression was evaluated on All-cause mortality (MRR 1.11, 95% CI 1.07-1.15). Pre-admission depression increased the risk of all-cause mortality following myocardial infarction by 11% compared to patients without previous depression (MRR 1.11).