Severe arterial stiffness combined with poor glycemic control significantly increased the risk of macrovascular complications (HR 2.73) compared to normal arterial stiffness and good glycemic control in patients with type 2 diabetes.
Cohort (n=1,870)
No
Does a combined evaluation of arterial stiffness, glycemic control, and hypertension predict the risk of macrovascular complications in patients with type 2 diabetes?
A combined evaluation of arterial stiffness, glycemic control, and hypertension status effectively stratifies the risk of macrovascular complications in patients with type 2 diabetes.
Effect estimate: HR 2.73 (95% CI 1.42-5.25)
Absolute Event Rate: 29.1% vs 8.2%
p-value: p=0.003
BACKGROUND: Arterial stiffness, glycemic control and blood pressure are risk factors of macrovascular complications in type 2 diabetes. This study aimed to investigate the combined association of arterial stiffness, glycemic control and hypertension status with the occurrence of diabetic macrovascular complication. METHODS: A total of 1870 patients of diabetes were enrolled from Beijing Health Management Cohort between 2008 and 2018 as baseline, and then followed for macrovascular complication onset. We proposed a composite risk score (0-4) by arterial stiffness severity, pool glycemic control and hypertension status. Cox model was used to estimate the hazard ratio (HR) and 95% confidence interval (CI). RESULTS: The mean age (SD) of this population was 59.90 (12.29) years. During a median follow-up of 4.0 years, 359 (19.2%) patients developed macrovascular complication. Compared to the normal arterial stiffness and good glycemic control group, patients with severe arterial stiffness and pool glycemic control had the highest risk of macrovascular complications (HR: 2.73; 95% CI: 1.42-5.25). Similarly, those of severe arterial stiffness and hypertension had the highest risk (HR: 2.69; 95% CI: 1.61-4.50). Patients of the composite score > 2 had a significantly increased risk of macrovascular complication. CONCLUSION: This study suggested the clinical importance of combined evaluation of arterial stiffness, glycemic control and hypertension status for the risk stratification and management of macrovascular complication of type 2 diabetes.
Wu et al. (Mon,) conducted a cohort in Type 2 diabetes (n=1,870). Severe arterial stiffness and poor glycemic control vs. Normal arterial stiffness and good glycemic control was evaluated on Macrovascular complications (coronary artery disease, cerebrovascular disease, and peripheral arterial disease) (HR 2.73, 95% CI 1.42-5.25, p=0.003). Severe arterial stiffness combined with poor glycemic control significantly increased the risk of macrovascular complications (HR 2.73) compared to normal arterial stiffness and good glycemic control in patients with type 2 diabetes.