Directed medical therapy for moderate to severe pulmonary arterial hypertension during pregnancy resulted in 100% maternal survival at a mean follow-up of 8 years.
Observational (n=10)
No
Does directed medical therapy allow for safe pregnancy and delivery in women with moderate to severe pulmonary arterial hypertension?
In a single-center experience, directed medical therapy allowed 10 women with moderate to severe PAH to survive pregnancy and delivery with 100% long-term survival at 8 years, despite frequent peripartum complications.
Pulmonary arterial hypertension (PAH) is a disease characterized by increased pulmonary vascular resistance (PVR). Pregnancy in the setting of PAH is associated with significant maternal morbidity and mortality, typically present during labor and the early postpartum. Historically, observed maternal mortality has been as high as 56%. However, with improved recognition, understanding, and treatment of PAH, reassessment of maternal outcomes is of increasing interest. This is a retrospective observational case series of all women with a diagnosis of moderate to severe World Health Organization Group 1 PAH who had pregnancy managed in our tertiary care center between 2004 and 2018. Ten women (Age 28 SD 6 years, mean pulmonary artery pressure 48 SD 16.5 mmHg, PVR 7.5 SD 4.3 Wood units) were identified and included. Seven women (70%) had an antepartum diagnosis of PAH, 2 women (20%) were diagnosed during pregnancy and 1 (10%) postpartum. Four women (40%) delivered preterm, and 3 women (30%) had a successful vaginal delivery. Cardiovascular complications occurred in 4 women (40%) and non-cardiovascular complications occurred in 5 women (50%). There were no significant changes in right ventricular function or non-invasive assessment of PA pressures at long-term follow-up. All patients are alive to date at a mean follow-up of 8 SD 4 years. In our single center, 10 women with moderate to severe PAH receiving directed medical therapy survived pregnancy and delivery. Further evaluation and review are required to optimize medical management for women with PAH who pursue pregnancy.
Lastinger et al. (Sun,) conducted a observational in Moderate to severe World Health Organization Group 1 pulmonary arterial hypertension in pregnancy (n=10). Directed medical therapy for PAH was evaluated on Maternal survival. Directed medical therapy for moderate to severe pulmonary arterial hypertension during pregnancy resulted in 100% maternal survival at a mean follow-up of 8 years.