Coronary revascularization (both PCI and CABG) had significantly greater positive effects on health-related quality of life compared to medication treatment, with moderate long-term effect sizes.
Meta-Analysis (n=15,992)
Does coronary revascularization improve Health-Related Quality of Life in cardiac patients compared to medication treatment?
Coronary revascularization (PCI or CABG) significantly improves long-term health-related quality of life compared to medical therapy alone in cardiac patients.
OBJECTIVE: To conduct a systematic review and meta-analysis to summarize evidence and determine the impact of coronary revascularization (CR) on cardiac patients' Health-Related Quality of Life (HRQoL), highlighting factors that may affect this outcome in patients. METHODS: A systematic search of Medline (Pubmed), EMBASE, Cochrane Library, Sciverse (Science Direct and Scopus) and PsycInfo was conducted to identify studies published from January 2000 to December 2012. Data were analyzed using MIX 2.0 Pro and SPSS 20. RESULTS: Thirty-four longitudinal studies met the inclusion criteria; these studies included 15,992 patients, of whom 8,027 had undergone PCI, 6,348 had undergone CABG and 1,617 had received medication treatment. Moderate long-term effect sizes were revealed for both CR procedures. Both percutaneous coronary interventions (PCI) and coronary artery bypass graft surgery (CABG) had significantly greater effects on HRQoL than did medication; however, the CR procedures did not differ significantly from each other. Moderators included the type of instrument used to assess HRQoL and the study quality. Benefits related to physical functioning were greater than those related to psychosocial functioning in patients treated with CABG. CONCLUSIONS: Empirical research highlights the positive effect of CR on patient HRQoL. Researchers should carefully select the instrument they use to measure HRQoL, as this may affect the results and thus conclusions. More RCTs and between-group studies employing pre-post designs should be conducted before clear conclusions can be drawn.
Takousi et al. (Fri,) conducted a meta-analysis in Cardiac patients requiring coronary revascularization (n=15,992). Coronary revascularization (PCI or CABG) vs. Medication treatment was evaluated on Health-Related Quality of Life (HRQoL). Coronary revascularization (both PCI and CABG) had significantly greater positive effects on health-related quality of life compared to medication treatment, with moderate long-term effect sizes.