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Three cases of malignant melanoma occurring in a mother and two adult sons in a family of eleven are reported. The pedigree of this family was studied in regard to individual eye color, hair color, and complexion. The findings support the generally accepted belief that malignant melanoma is more common in blue-eyed blonds with a light complexion. A cytogenetic study of leukocyte and skin tissue cultures is described. The results revealed a normal diploid number of chromosomes46and a normal karyotype in the mother and one son. The implications of the findings in reference to the cases of familial malignant melanoma and the potentialities of tremendous advances in molecular biochemistry and genetics are discussed.
E. P. Schoch (Tue,) studied this question.