A body mass index ≥28 kg/m2 was associated with an increased risk of ischaemic stroke compared with normal BMI (HR 1.36; 95% CI 1.09-1.80; p<0.001) among elderly Chinese hypertensive patients.
Cohort (n=3,315)
Does higher BMI increase the risk of ischaemic stroke in elderly hypertensive patients?
Higher BMI is an independent risk factor for new-onset ischaemic stroke in elderly Chinese patients with hypertension.
Effect estimate: HR 1.36 (95% CI 1.09 to 1.80)
p-value: p=<0.001
ABSTRACT Background Despite obesity being a major risk factor for ischaemic stroke (IS), the association between body mass index (BMI) and IS in patients with hypertension remains uncertain. Objective To assess the association between BMI and IS among elderly hypertensive patients in China. Methods and results We recruited 3500 hypertensive patients aged ≥60 between 1 January 2010 and 31 December 2011 in China and ascertained their stroke status until December 2016. Multivariate Cox regression was used to evaluate the association between BMI and IS with interaction tests for exposure and covariates. A total of 3315 subjects (mean age 71.41±7.20 years, 44.5% were men) were included for data analysis. During an average follow-up period of 5.5 years, there were 206 onset cases (6.21%) of IS. When BMI was treated as a continuous variable, it was positively associated with the incidence of new onset IS (HR=1.14; 95% CI: 1.05 to 1.34; p=0.005) after adjusting for potential confounders. Meanwhile, when BMI was treated as a categorical variable, the highest category (≥28 kg/m2) was strongly associated with an increased risk for IS compared with normal BMI category (18.5 to 24 kg/m2) (HR=1.36, 95% CI: 1.09 to 1.80; p0.001) in the fully adjusted model. Subgroup and interaction analysis also demonstrated that BMI independently associated with IS among males, smokers, alcohol drinkers, diabetic patients, people with uncontrolled blood pressure, decreased estimated glomerular filtration rate and those aged ≥70 years. Conclusion BMI was significantly associated with IS and was an independent risk of IS in Chinese elderly hypertensive patients.
Huang et al. (Fri,) conducted a cohort in Hypertension (n=3,315). Body mass index (BMI) ≥28 kg/m2 vs. Normal BMI (18.5 to 24 kg/m2) was evaluated on Incidence of new onset ischaemic stroke (HR 1.36, 95% CI 1.09 to 1.80, p=<0.001). A body mass index ≥28 kg/m2 was associated with an increased risk of ischaemic stroke compared with normal BMI (HR 1.36; 95% CI 1.09-1.80; p<0.001) among elderly Chinese hypertensive patients.
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