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syndrome need to be based on population data that include births and terminations of pregnancy.We acknowledge the role of South Australian midwives and neonatal nurses in providing perinatal data and of doctors in providing data on congenital abnormalities; the contribution of staff of the South Australian Births Defects Register and the Pregnancy Outcome Unit in processing and collating data on babies with Down's syndrome, births, and terminations of pregnancy; and the staff of the department of cytogenetics and molecular genetics, Women's and Children's Hospital, and of the department of cytogenetics, Queen Elizabeth Hospital, for providing cytogenetic data.Contributors: AC initiated and planned the study, reviewed the literature, performed the univariate analysis, participated in the interpretation of data, and wrote the paper.KAM performed the Poisson regression analysis and participated in the planning of the study, the interpretation of data, and writing the paper.RJK participated in the planning of the study, the validation of some case details, the retrieval and preparation of data for analysis, and editing the manuscript.EAH participated in planning the study, interpreting the data, and editing the manuscript.
Salmon et al. (Sat,) studied this question.
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