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Abstract Immunoglobulins (Ig) have recently been found to be present on the surface of small lymphocytes in the peripheral organs of mouse, human and rabbit by autoradiographic and immunofluorescence techniques using radiolabeled or fluorescein-labeled anti-immunoglobulin antisera (1–3). However, not all lymphocytes contain detectable amounts of immunoglobulins. Whereas approximately 50% of spleen cells and the majority of bone marrow lymphocytes contain surface immunoglobulins in the mouse, only 10% to 20% of the lymphocytes in peripheral blood and lymph nodes, and less than 1% of thymic lymphocytes contain detectable immunoglobulin (3). The lowest concentrations of lymphocytes with surface immunoglobulin were found in areas in which thymic-derived cells are thought to predominate (4). This suggested that the Ig positive cells were of bone marrow origin and that the negative cells were thymus-derived.
Rabellino et al. (Sat,) studied this question.