High circulating adiponectin level was independently associated with clinical recurrence of AF after catheter ablation (HR 1.17; 95% CI 1.02-1.35; P=0.022), especially in patients <65 years.
Cohort (n=874)
Does high pre-procedural plasma adiponectin predict clinical recurrence of atrial fibrillation in patients undergoing catheter ablation for paroxysmal AF?
High pre-procedural circulating adiponectin levels independently predict atrial fibrillation recurrence after catheter ablation in patients with paroxysmal AF, particularly in those under 65 years of age.
Effect estimate: HR 1.17 (95% CI 1.02-1.35)
p-value: p=0.022
Aims: Circulating adiponectin is known to have anti-diabetic, anti-atherogenic, and anti-inflammatory properties. However, the predictive value of adiponectin in cardiovascular disease has been reported to be contradictory ('adiponectin paradox') and its relationship with atrial fibrillation (AF) is controversial. We hypothesized that pre-procedural plasma level of adiponectin would have prognostic value in patients who underwent AF catheter ablation. Methods and results: This observational cohort study included 874 patients with paroxysmal AF (PAF) (73.0% male, mean age 57.6 ± 11.2 years) who underwent catheter ablation. Quartile analyses of plasma level of adiponectin were performed to determine AF-related clinical factors. Patients in the highest quartile of plasma adiponectin were more likely to be older (P < 0.001), female (P < 0.001), and have a higher CHA2DS2-VASc score (P < 0.001) than patients in the other three quartiles. Plasma level of adiponectin was independently associated with female gender (B 2.92 1.84∼4.00, P < 0.001), older age (B 0.06 0.03∼0.10, P < 0.001), lower body mass index (B - 0.22 -0.42∼-0.03, P = 0.025), and greater LA volume index (B 0.05 0.01∼0.08, P = 0.005). During the 29.9 ± 18.0 months of follow-up, plasma adiponectin level (HR 1.17 1.02∼1.35, P = 0.022) was independently associated with clinical recurrence of AF, and the clinical recurrence rate was significantly higher in the highest quartile of adiponectin group than the others (log rank P = 0.029), especially in age <65 years (log rank P = 0.038), but not in age ≥65. Conclusion: High circulating adiponectin is independently associated with AF recurrence after catheter ablation for PAF, especially younger than 65 years old.
Kim et al. (Wed,) conducted a cohort in paroxysmal atrial fibrillation (n=874). High circulating adiponectin level vs. Lower adiponectin levels was evaluated on clinical recurrence of AF (HR 1.17, 95% CI 1.02-1.35, p=0.022). High circulating adiponectin level was independently associated with clinical recurrence of AF after catheter ablation (HR 1.17; 95% CI 1.02-1.35; P=0.022), especially in patients <65 years.