Hydrochlorothiazide 25 mg was similarly effective to 50 mg in controlling blood pressure (78% vs 89%) in elderly patients with isolated systolic hypertension, but caused less serum potassium reduction.
RCT (n=51)
Double-blind
randomized
Does 25 mg of hydrochlorothiazide compared to 50 mg provide similar blood pressure reduction with better safety in elderly patients with isolated systolic hypertension?
Hydrochlorothiazide 25 mg is effective and well tolerated for isolated systolic hypertension in the elderly, offering similar blood pressure control to 50 mg with less potassium depletion.
Absolute Event Rate: 78% vs 89%
In a double-blind randomized study, we evaluated the effects of 25 mg vs 50 mg of hydrochlorothiazide in 51 elderly patients (aged 68.9+-7.0 years) with isolated systolic hypertension (blood pressure, 160 to 239 mm Hg systolic and Arch Intern Med. 1991;151:1954-1960)
William C. Cushman (Tue,) conducted a rct in isolated systolic hypertension (n=51). hydrochlorothiazide vs. 50 mg hydrochlorothiazide was evaluated on Proportion of patients in whom blood pressure was controlled. Hydrochlorothiazide 25 mg was similarly effective to 50 mg in controlling blood pressure (78% vs 89%) in elderly patients with isolated systolic hypertension, but caused less serum potassium reduction.
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