Type 1 diabetes mellitus in young adults is associated with subclinical left ventricular systolic dysfunction, evidenced by reduced global longitudinal strain (-20.3% vs. -22.2%, P<0.001).
Observational (n=100)
Is type 1 diabetes mellitus associated with impaired left and right ventricular systolic function assessed by 2D speckle tracking echocardiography in young adults?
Type 1 diabetes mellitus is associated with subclinical left and right ventricular systolic dysfunction detectable by 2D speckle tracking echocardiography.
Absolute Event Rate: -20.3% vs -22.2%
p-value: p=<0.001
AIMS: Subclinical left ventricular (LV) and right ventricular (RV) systolic dysfunction has been proved in type 2 diabetes mellitus (DM). There is lack of uniform data on systolic myocardial function in type 1 DM. The aim of this study was to evaluate LV and RV function with 2D speckle tracking echocardiography (2D STE) in adult type 1 diabetic patients. METHODS AND RESULTS: Totally, 50 patients with type 1 DM and 50 control subjects in the same range of age were prospectively evaluated. The 2D STE assessment of LV longitudinal, radial, circumferential strain and RV free-wall longitudinal strain was performed. In diabetic group, left ventricular global longitudinal strain (LVGLS), left ventricular global circumferential strain (LVGCS), left ventricular radial strain at basal level (LVRS-basal), and right ventricular free-wall global longitudinal strain (RVGLS) were significantly lower compared with the controls: LVGLS (-20.3 ± 2.0% vs. -22.2 ± 1.8%, P < 0.001), LVGCS (-21.1 ± 2.5% vs. -22.2 ± 2.4%, P < 0.05), LVRS-basal (50.5% ± 11.5 vs. 57.1% ±17.0, P < 0.05), and RVGLS (-30.1% ± 3.5 vs. -32.7% ± 3.9, P < 0.01). Multivariable logistic regression analysis showed that the only independent predictor of reduced LVGLS was low-density lipoprotein cholesterol odds ratio 3.65 (95% confidence interval: 1.27-10.5), P = 0.014. CONCLUSION: Type 1 DM is associated with subclinical LV systolic dysfunction and worse RV systolic function, which can be detected with 2D STE.
Jedrzejewska et al. (Thu,) conducted a observational in Type 1 diabetes mellitus (n=100). Type 1 diabetes mellitus vs. Control subjects was evaluated on Left ventricular global longitudinal strain (LVGLS) (p=<0.001). Type 1 diabetes mellitus in young adults is associated with subclinical left ventricular systolic dysfunction, evidenced by reduced global longitudinal strain (-20.3% vs. -22.2%, P<0.001).