Increased use of oral anticoagulants between 2012 and 2017 was associated with a decrease in ischemic stroke incidence from 2.01 to 1.17 per 100 person-years (IRR 0.58; 95% CI 0.52-0.65).
Observational (n=90,518)
Does increased use of non-vitamin K antagonist oral anticoagulants reduce ischemic stroke and bleeding in patients with atrial fibrillation?
Increased adoption of NOACs in real-world clinical practice is associated with a marked reduction in ischemic stroke without increasing major bleeding rates in patients with atrial fibrillation.
Effect estimate: IRR 0.58 (95% CI 0.52-0.65)
Absolute Event Rate: 1.17% vs 2.01%
Background and Purpose— The purpose of this study was to investigate the impact of improved antithrombotic treatment in atrial fibrillation after the introduction of non–vitamin K antagonist oral anticoagulants on the incidence of stroke and bleeding in a real-life total population, including both primary and secondary care. Methods— All resident and alive patients with a recorded diagnosis for atrial fibrillation during the preceding 5 years in the Stockholm County Healthcare database (Vårdanalysdatabasen) were followed for clinical outcomes during 2012 (n=41 008) and 2017 (n=49 510). Results— Pharmacy claims for oral anticoagulants increased from 51.6% to 73.8% (78.7% among those with CHA 2 DS 2 -VASc ≥2). Non–vitamin K antagonist oral anticoagulant claims increased from 0.4% to 34.4%. Ischemic stroke incidence rates decreased from 2.01 per 100 person-years in 2012 to 1.17 in 2017 (incidence rate ratio, 0.58; 95% CI, 0.52–0.65). The largest increases in oral anticoagulants use and decreases in ischemic strokes were seen in patients aged ≥80 years who had the highest risk of stroke and bleeding. The incidence rates for major bleeding (2.59) remained unchanged (incidence rate ratio, 1.00; 95% CI, 0.92–1.09) even in those with a high bleeding risk. Poisson regression showed that 10% of the absolute ischemic stroke reduction was associated with increased oral anticoagulants treatment, whereas 27% was related to a generally decreased risk for all stroke. Conclusions— Increased oral anticoagulants use contributed to a marked reduction of ischemic strokes without increasing bleeding rates between 2012 and 2017. The largest stroke reduction was seen in elderly patients with the highest risks for stroke and bleeding. These findings strongly support the adoption of current guideline recommendations for stroke prevention in atrial fibrillation in both primary and secondary care.
Forslund et al. (Sat,) conducted a observational in Atrial fibrillation (n=90,518). Oral anticoagulants (including non-vitamin K antagonist oral anticoagulants) vs. 2012 cohort (historical control) was evaluated on Ischemic stroke incidence (IRR 0.58, 95% CI 0.52-0.65). Increased use of oral anticoagulants between 2012 and 2017 was associated with a decrease in ischemic stroke incidence from 2.01 to 1.17 per 100 person-years (IRR 0.58; 95% CI 0.52-0.65).