Combined exposure to inhaled nicotine and high-fat diet in mice resulted in unique cardiovascular consequences, including left ventricular diastolic dysfunction, compared with either treatment alone.
Nicotine product usage and high-fat diet consumption are two modifiable risk factors for cardiovascular diseases. Here, we demonstrate that in mice, combined exposure to inhaled nicotine and high-fat diet results in unique cardiovascular consequences compared with either treatment alone, including left ventricular diastolic dysfunction, dysregulation of blood pressure, autonomic dysfunction, and greater impairment of endothelium-dependent vasorelaxation. These findings indicate that individuals who consume both nicotine products and high-fat diet have distinctive cardiovascular risks.
Whitehead et al. (Fri,) conducted a other in Cardiovascular dysfunction. Combined exposure to inhaled nicotine and high-fat diet vs. Either treatment alone was evaluated on Cardiovascular consequences including left ventricular diastolic dysfunction, dysregulation of blood pressure, autonomic dysfunction, and impairment of endothelium-dependent vasorelaxation. Combined exposure to inhaled nicotine and high-fat diet in mice resulted in unique cardiovascular consequences, including left ventricular diastolic dysfunction, compared with either treatment alone.