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Spontaneously hypertensive rats exhibit vectorcardiographic changes, including shifted QRS loops and increased QRS-T angles, that closely resemble the patterns of left ventricular hypertrophy in humans. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 1985Open Access

Vectorcardiogram with McFee-Parungao lead system in spontaneously hypertensive rats.

Structured PICO

What are the vectorcardiographic characteristics of spontaneously hypertensive rats compared to normal rats?

Population

5 spontaneously hypertensive rats (SHR) and 5 age-matched normal wistar rats (WR)

Intervention

Vectorcardiogram (VCG) recording using the McFee-Parungao lead system

Comparator

Normal wistar rats (WR)

Outcome

Vectorcardiographic characteristics (QRS loops, QRS-T angles)surrogate

Vectorcardiographic findings in spontaneously hypertensive rats are similar to those produced by left ventricular hypertrophy in humans.

Abstract

Vectorcardiograms (VCG) were recorded from five spontaneously hypertensive rats (SHR) and five age-matched normal wistar rats (WR). Arterial systolic blood pressure was 115 +/- 10.8 mmHg in WR and 176 +/- 7.7 mmHg in SHR. The basic procedures for recording VCG in the rat were investigated. After rats were anesthetized with urethane-chloralose, VCG were taken by using the McFee-Parungao lead system in restrained ventral position. VCG in SHR were characterized by superior, posterior and leftward shift of QRS loops, a more elliptical form of QRS loops in the horizontal plane, and an increase in QRS-T angles in all planes, when compared with WR. These vectorcardiographic findings in SHR were quite similar to those produced by left ventricular hypertrophy in humans.

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