Laboratory-confirmed respiratory infections were significantly associated with MI and ischemic stroke hospitalizations in the elderly, accounting for an estimated 0.4%-5.7% of these admissions.
Observational
Yes
Background: Acute respiratory infections are associated with increased risk of myocardial infarction (MI) and stroke; however, the role of different organisms is poorly characterized. Methods: Time-series analysis of English hospital admissions for MI and stroke (age-stratified: 45-64, 65-74, ≥75 years), laboratory-confirmed viral respiratory infections, and environmental data for 2004-2015. Weekly counts of admissions were modeled using multivariable Poisson regression with weekly counts of respiratory viruses (influenza, parainfluenza, rhinovirus, respiratory syncytial virus RSV, adenovirus, or human metapneumovirus HMPV) investigated as predictors. We controlled for seasonality, long-term trends, and environmental factors. Results: Weekly hospital admissions in adults aged ≥45 years averaged 1347 (interquartile range IQR, 1217-1541) for MI and 1175 (IQR, 1023-1395) for stroke. Respiratory infections ranged from 11 cases per week (IQR, 5-53) for influenza to 55 (IQR, 7-127) for rhinovirus. In the adjusted models, all viruses except parainfluenza were significantly associated with MI and ischemic stroke admissions in those aged ≥75. Among 65- to 74-year-olds, adenovirus, rhinovirus, and RSV were associated with MI but not ischemic stroke admissions. Respiratory infections were not associated with MI or ischemic stroke in people aged 45-64 years, nor with hemorrhagic stroke in any age group. An estimated 0.4%-5.7% of MI and ischemic stroke admissions may be attributable to respiratory infection. Conclusions: We identified small but strongly significant associations in the timing of respiratory infection (with HMPV, RSV, influenza, rhinovirus, and adenovirus) and MI or ischemic stroke hospitalizations in the elderly. Clinical Trials Registration: NCT02984280.
Blackburn et al. (Fri,) conducted a observational in Myocardial infarction and stroke. Laboratory-confirmed viral respiratory infections was evaluated on Hospital admissions for MI and stroke. Laboratory-confirmed respiratory infections were significantly associated with MI and ischemic stroke hospitalizations in the elderly, accounting for an estimated 0.4%-5.7% of these admissions.