Over an 8-year period, the rate of hospital admissions for AMI fell to a greater extent in the diabetic population compared to the nondiabetic population (-15.1% vs. -9.1%, P<0.0001).
Cohort (n=9,861,323)
How do recent trends in cardiovascular disease outcomes compare between adults with and without diabetes?
While the rate of cardiovascular events decreased more in the diabetic population over an 8-year period, the absolute burden of CVD increased due to a rising prevalence of diabetes.
Absolute Event Rate: -15.1% vs -9.1%
p-value: p=<0.0001
OBJECTIVE: To compare recent trends in cardiovascular disease (CVD) outcomes among men and women with diabetes with those in the nondiabetic population. RESEARCH DESIGN AND METHODS: We conducted a retrospective cohort study using provincial health claims data to identify adults with (n = 670,602) and without (n = 9,190,721) diabetes living in Ontario, Canada, between 1 April 1992 and 31 March 2000. We compared changes in the annual age-/sex-adjusted rates and numbers of subjects admitted for acute myocardial infarction (AMI) and stroke and of deaths from AMI, stroke, and all causes between those with and without diabetes. RESULTS: Over the 8-year period, the rate of patients admitted for AMI and stroke fell to a greater extent in the diabetic than the nondiabetic population (AMI: -15.1 vs. -9.1%, P < 0.0001; stroke: -24.2 vs. 19.4%, P < 0.0001). Diabetic patients experienced similar reductions in case-fatality rates related to AMI and stroke than those without diabetes (-44.1 vs. -33.2%, P = 0.1; -17.1 vs. -16.6%, P = 0.9, respectively). Declines in all-cause mortality were also comparable in the two populations. Over the same period, the number of diabetes cases increased from 405,471 to 670,602. Thus, while CVD rates fell, the number of events occurring in this population rose substantially (AMI: +44.6%, stroke: +26.1%, AMI deaths: +17.2%, and stroke deaths: +13.2%). CONCLUSIONS: Our findings demonstrate a significant reduction in the rate of people affected by CVD within the diabetic population. However, as the number of people with diabetes rises, so may the absolute burden of CVD in our society.
Booth et al. (Sun,) conducted a cohort in Diabetes and cardiovascular disease (n=9,861,323). Diabetes vs. Nondiabetic population was evaluated on Change in annual age-/sex-adjusted rate of subjects admitted for acute myocardial infarction (AMI) (p=<0.0001). Over an 8-year period, the rate of hospital admissions for AMI fell to a greater extent in the diabetic population compared to the nondiabetic population (-15.1% vs. -9.1%, P<0.0001).