Second-generation cryoballoon-based pulmonary vein isolation in patients with HFrEF resulted in 73.1% 12-month freedom from AF recurrence, comparable to 72.6% in patients with preserved LVEF (P=0.25).
Observational (n=551)
Yes
Does second-generation cryoballoon-based pulmonary vein isolation safely prevent AF recurrence in patients with HFrEF compared to those with preserved LVEF?
Cryoballoon ablation for atrial fibrillation in patients with HFrEF is safe and achieves similar 12-month freedom from AF recurrence as in patients with preserved LVEF, while significantly improving LVEF and NYHA class.
Absolute Event Rate: 73.1% vs 72.6%
p-value: p=0.25
BACKGROUND: Second-generation cryoballoon (CB2)-based pulmonary vein isolation (PVI) has demonstrated encouraging results in the treatment of atrial fibrillation (AF). This study sought to assess data on the safety, efficacy and clinical success of CB2-based PVI in patients with heart failure (HF) and reduced ejection fraction (HFrEF). METHODS AND RESULTS: CB2-based PVI was performed in 551 consecutive patients in 3 highly experienced EP centers. Patients with HF and LVEF ≤40% were included (HFrEF group, n=50/551, 9.1%). Data were compared with propensity score-matched patients without HF and preserved left ventricular EF (LVEF) (n=50, control group). The median LVEF was HFrEF: 37% (35, 40) and control: 55% (55, 55), P<0.0001. Major periprocedural complications were registered in 4/50 (8%, HFrEF group) and 3/50 (6%, control group), P=0.695. The 12-month freedom from AF recurrence was 73.1% (95% confidence interval (CI): 61-88, HFrEF group) and 72.6% (95% CI: 61-87, control group), P=0.25. NYHA class decreased from 2.4±0.8 (baseline) to 1.7±0.8 at 12-month follow-up (P<0.0001). LVEF improved from a median of 37% (35, 40) prior to ablation to a median of 55% (40, 55), P<0.0001. CONCLUSIONS: CB2-based PVI in patients with HFrEF appeared to be safe, was associated with comparable periprocedural complications and showed promising clinical success rates equal to those for patients with preserved LVEF. NYHA class and LVEF significantly improved at 12-month follow-up.
Heeger et al. (Thu,) conducted a observational in Atrial fibrillation and heart failure with reduced ejection fraction (n=551). Second-generation cryoballoon-based pulmonary vein isolation vs. Propensity score-matched patients without heart failure and preserved LVEF was evaluated on 12-month freedom from AF recurrence (p=0.25). Second-generation cryoballoon-based pulmonary vein isolation in patients with HFrEF resulted in 73.1% 12-month freedom from AF recurrence, comparable to 72.6% in patients with preserved LVEF (P=0.25).