High-sensitivity cardiac troponin I testing rapidly ruled out acute coronary syndrome in more patients than contemporary-sensitive testing (68.7% vs 52.4%) and reduced emergency department stay.
Observational (n=288)
Does high-sensitivity cardiac troponin I (HS-cTnI) testing improve early rule-out of ACS and reduce emergency department length of stay compared to conventional CS-cTnI in patients with suspected ACS?
High-sensitivity cardiac troponin I testing allows for more rapid rule-out of ACS and shorter emergency department stays compared to conventional troponin testing.
Absolute Event Rate: 68.7% vs 52.4%
Background: Although high-sensitivity (HS) cardiac troponin I (cTnI) immunoassays have enhanced efficiency for early rule-out of acute coronary syndrome (ACS) compared to contemporary-sensitive (CS) techniques, no reliable information has been published in support of their cost-effectiveness. Therefore, this study was designed to evaluate the clinical, economic and organizational advantages of using a HS-cTnI immunoassay compared to a conventional CS-cTnI technique for early management of patients admitted to the emergency department (ED) with suspected ACS. Methods: The study population consisted of 288 consecutive patients admitted to the ED for suspected ACS over a 3-month period. cTnI was measured with both HS-cTnI and CS-cTnI immunoassays. The clinical, economic and organizational impact was analyzed according to patient management based upon results of either method. Results: ACS could be rapidly ruled out in a larger number of patients using HS-cTnI than CS-cTnI (68.7% versus 52.4%). The overall stay in the ED for ACS diagnostics was nearly 20% shorter using HS-cTnI than using CS-cTnI (1.9±1.4 versus 2.4±1.5 hour/patient; P
Lippi et al. (Thu,) conducted a observational in Suspected acute coronary syndrome (ACS) (n=288). High-sensitivity cardiac troponin I (HS-cTnI) immunoassay vs. Contemporary-sensitive (CS) cTnI immunoassay was evaluated on Rapid rule-out of acute coronary syndrome. High-sensitivity cardiac troponin I testing rapidly ruled out acute coronary syndrome in more patients than contemporary-sensitive testing (68.7% vs 52.4%) and reduced emergency department stay.