Salt sensitivity is present in about half of people with essential hypertension, driven by subclinical renal injury over time that leads to arteriolosclerosis and tubulointerstitial disease.
This review highlights the mechanistic role of acquired subclinical renal injury in the development of salt-sensitive essential hypertension.
Salt sensitivity is present in about half of people with essential hypertension; decreasing salt intake ameliorates the hypertension. This review provides an explanation of how initially subtle renal injury promotes a tendency toward hypertension. The kidneys, initially normal in many persons with early primary hypertension, sustain subclinical injury over time, resulting in arteriolosclerosis and tubulointerstitial disease that lead to established hypertension.
Johnson et al. (Thu,) conducted a review in Essential hypertension. Salt sensitivity is present in about half of people with essential hypertension, driven by subclinical renal injury over time that leads to arteriolosclerosis and tubulointerstitial disease.