Plasma NT-proBNP levels were significantly higher in black African subjects with hypertensive heart failure compared to those with hypertension and left ventricular hypertrophy (p < 0.0002).
Cohort (n=210)
No
Does plasma NT-proBNP differentiate hypertension with or without LVH from hypertensive heart failure and correlate with cardiac remodeling in black African subjects?
Plasma NT-proBNP is a useful biomarker for differentiating hypertensive heart failure from hypertension with or without LVH in black African patients, and correlates with right atrial remodeling.
p-value: p=<0.0002
AIM: Although plasma NT-proBNP differentiates hypertension (HT) with or without left ventricular hypertrophy (LVH) from hypertensive heart failure (HHF), most of the published data are based on studies in Western populations. Also, most previous studies did not consider left ventricular (LV) diastolic function and right ventricular (RV) function. We therefore examined the relation between NT-proBNP on LV and RV remodelling in an African hypertensive cohort. METHODS: Subjects were subdivided into three groups after echocardiography: hypertensives without LVH (HT) (n = 83); hypertensives with LVH (HT + LVH) (n = 50); and those with hypertensive heart failure (HHF) (n = 77). RESULTS: Subjects with HHF had significantly higher NT-proBNP levels compared to the HT + LVH group (p < 0.0002). NT-proBNP correlated positively with right atrial area, an indirect measure of RV function. CONCLUSIONS: NT-proBNP is proposed as a useful biomarker in differentiating hypertension with or without LVH from hypertensive heart failure in black hypertensive subjects.
Ojji et al. (Tue,) conducted a cohort in Hypertension and hypertensive heart failure (n=210). NT-proBNP measurement vs. Hypertension with or without left ventricular hypertrophy was evaluated on Difference in NT-proBNP levels between hypertensive heart failure and hypertension with left ventricular hypertrophy (p=<0.0002). Plasma NT-proBNP levels were significantly higher in black African subjects with hypertensive heart failure compared to those with hypertension and left ventricular hypertrophy (p < 0.0002).