Health-related quality of life did not significantly improve over two years (EQ-5D index 0.76 to 0.78, p=0.28) despite a significant reduction in chest pain severity in patients with coronary artery disease.
Cohort (n=253)
No
In patients with coronary artery disease, health-related quality of life remains largely unresponsive to improvements in chest pain symptoms over a 2-year period.
Absolute Event Rate: 0.78% vs 0.76%
p-value: p=0.28
BACKGROUND: There is at present a lack of knowledge of time trends in health related quality of life (HRQL) in common patients with coronary artery disease (CAD) treated in ordinary care. The objective of this study is to assess and compare time trends of health related quality of life (HRQL) and chest pain in patients with coronary artery disease. METHODS: 253 consecutive CAD patients in Stockholm County, Sweden--197 males/56 females; 60 +/- 8 years--were followed during two years. Perceived chest pain symptoms and three global assessments of HRQL were assessed at baseline, after one and after two years. EuroQol-5 dimension (EQ-5D) with a predefined focus on function and symptoms; the broader tapping global estimates of HRQL; EuroQol VAS (EQ-VAS) and Cardiac Health Profile (CHP) were used. Chest pain was ranked according to Canadian Cardiovascular Society (CCS). Change in HRQL was analysed by a repeated measurements ANOVA and chest pain symptoms were analysed by Friedman non-parametric ANOVA. RESULTS: Perceived chest pain decreased during the two years (p < 0.00022); CCS 0: 41-51%; CCS 1: 19-15%; CCS 2: 31-27%; CCS 3: 5-4% and CCS 4: 4-2%. By contrast, HRQL did not change: EQ-5D: 0.76 (CI 0.73-0.79) -0.78 (CI 0.75-0.81), EQ-VAS: 0.68 (CI 0.66-0.71)-0.68 (CI 0.65-0.71) and CHP: 0.66 (CI 0.64-0.69) -0.66 (CI 0.64-0.69). CONCLUSION: HRQL did not increase despite a reduction in the severity of chest pain during two years. This implies that the major part of HRQL in these consecutive ordinary patients with CAD is unresponsive to change in chest pain symptoms.
Kiessling et al. (Tue,) conducted a cohort in Coronary artery disease (n=253). Routine clinical care vs. Baseline was evaluated on Health related quality of life (EQ-5D index) (p=0.28). Health-related quality of life did not significantly improve over two years (EQ-5D index 0.76 to 0.78, p=0.28) despite a significant reduction in chest pain severity in patients with coronary artery disease.