Diffusion probabilistic models are powerful generative tools but are purely data-driven, limiting their ability to incorporate domain knowledge—such as physical laws, degradation trends, or engineering priors—in scientific and engineering applications. We introduce Prior-Guided Diffusion Processes (PGDPs), a unified mathematical framework that integrates arbitrary differentiable prior knowledge into the reverse diffusion dynamics by augmenting the score function with a guidance term derived from a prior potential V(x,t) and weighted by a time-dependent strength γt. This formulation subsumes existing mechanisms (classifier guidance, model-based diffusion, physics-informed corrections) as special cases. We analyze the guided path measures, providing an upper bound on the Kullback–Leibler divergence between guided and unguided marginals (Theorem 1), quantifying the inherent trade-off between data fidelity and prior satisfaction. Experiments on synthetic data confirm the predicted dependence on γt. On the NASA C-MAPSS turbofan benchmark, we enforce compressor-oriented physical constraints (e.g., speed–pressure consistency, monotonicity) within PGDP; remaining useful life scores are reported only as reference metrics under transparent protocols. A cross-domain study on the NASA IGBT accelerated aging dataset, using the same backbone with a replaced physics module, achieves a 99.98% reduction in monotonicity loss, demonstrating generality across distinct degradation mechanisms. PGDP provides a principled, extensible template for knowledge-informed generative modeling with theoretical guarantees and verifiable physical consistency.
Liu et al. (Fri,) studied this question.