A sequential polio immunization schedule using inactivated and live attenuated vaccines is hypothesized to provide optimal immunity, though well-designed clinical trials are needed to confirm this.
Does sequential use of IPV and OPV provide better immunity and prevent OPV-associated paralytic poliomyelitis compared to IPV or OPV alone in routine immunization?
Sequential use of IPV and OPV may provide optimal immunity and reduce vaccine-associated paralytic polio, but requires further clinical trials to establish specific recommendations.
Despite the concerns mentioned in the last section, there are many reasons to believe that a polio immunization schedule that incorporates sequential doses of inactivated poliovirus vaccine and live attenuated poliovirus vaccine would provide both humoral and intestinal immunity to the fully immunized person that is at least as good, if not better, than the immunity achieved by the use of IPV or OPV alone. A substantial degree of protection should also extend to partially immunized and unimmunized preschool aged children in the community. Furthermore most of the cases of OPV-associated paralytic poliomyelitis could be prevented. Because the reasons for these beliefs are based on data from small studies and on inferences from related research, specific recommendations for a change from current polio immunization policy must depend on additional clinical research. Well-designed trials comparing several different options for sequencing both inactivated and live vaccines are needed, and these studies should focus carefully on both humoral and intestinal immunity conferred by the various vaccine schedules.
McBean et al. (Thu,) conducted a review in Poliomyelitis. Sequential use of inactivated poliovirus vaccine and live attenuated poliovirus vaccine vs. IPV or OPV alone was evaluated. A sequential polio immunization schedule using inactivated and live attenuated vaccines is hypothesized to provide optimal immunity, though well-designed clinical trials are needed to confirm this.
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