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Three related classes of immunoglobulins ( 7S gamma(-), beta(2)A(-), and gamma(1)M(-) globulin) in normal C3H and C3H and C57BL/6 mouse serums were isolated and examined for the isoantigens Iga-1 and Iga-2. The results indicate that the genetic locus determining the Iga-1 and Iga-2 antigens affects only a portion of the normal mouse immunoglobulin population (that is, 7S gamma-globulin) and only the gamma-specific part ("F" piece) of the 7S gamma-globulin molecule.
Mishell et al. (Fri,) studied this question.
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