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Electrical field stimulation of guinea-pig stomach strips caused frequency related contractions that were enhanced by metoclopramide and SCH 23390 (10(-7)-10(-5) M) and antagonized by atropine (5 X 10(-8) M. 5-HT (3 X 10(-8)-3 X 10(-5) M) antagonized the ability of metoclopramide and SCH 23390 to enhance the contractions. It is concluded that metoclopramide and SCH 23390 can enhance electrical field stimulation-induced contractions in the stomach strips by a 5-HT receptor blockade which can facilitate cholinergic mediated contractions.
Gunning et al. (Tue,) studied this question.
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