Adrenocortical Steroids in the Management of Selected Patients With Infectious Diseases

Article1 July 1960ADRENOCORTICAL STEROIDS IN THE MANAGEMENT OF SELECTED PATIENTS WITH INFECTIOUS DISEASESWESLEY W. SPINK, M.D., F.A.C.P.WESLEY W. SPINK, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-53-1-1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt was pointed out in previous reviews on this subject that the judicious use of adrenocorticotropin and the corticosteroids frequently contributed to immediate improvement in the condition of patients seriously ill with infections and their complications.1, 2Additional evidence has been widely documented in the literature. That these steroids were potentially dangerous agents and should be administered cautiously was also emphasized. But accumulated clinical experience has not demonstrated serious side-effects, except in rare instances, when the adrenocorticosteroids were used over a brief period of time in critically ill patients. On the contrary, the benefits have far outweighed the hazards. However,...Bibliography1. Spink WW: Adrenocorticotropic hormone and adrenal steroids in the management of infectious diseases, Ann. Int. Med. 43: 685-701, 1955. LinkGoogle Scholar2. Spink WW: ACTH and adrenocorticosteroids as therapeutic adjuncts in infectious diseases, New England J. Med. 257: 979-983, 1031-1035, 1957. CrossrefMedlineGoogle Scholar3. WeilMacLeanVisscherSpink MHLDMBWW: Studies on the circulatory changes in the dog produced by endotoxin from Gram-negative microorganisms, J. Clin. Investigation 35: 1191-1198, 1956. CrossrefMedlineGoogle Scholar4. WeilMacLeanSpinkVisscher MHLDWWMB: Investigations on the role of the central nervous system in shock produced by endotoxin from Gram-negative microörganisms, J. Lab. and Clin. Med. 48: 661-672, 1956. MedlineGoogle Scholar5. WeilSpink MHWW: A comparison of shock due to endotoxin with anaphylactic shock, J. Lab. and Clin. Med. 50: 501-515, 1957. MedlineGoogle Scholar6. WeilSpink MHWW: The shock syndrome associated with bacteremia due to Gram-negative bacilli, Arch. Int. Med. 101: 184-193, 1958. CrossrefGoogle Scholar7. Spink WW: From endotoxin to snake venom, Yale J. Biol. and Med. 30: 355-367, 1958. MedlineGoogle Scholar8. MelbySpink JCWW: Comparative studies on adrenal cortical function and Cortisol metabolism in healthy adults and in patients with shock due to infection, J. Clin. Investigation 137: 1791-1798, 1958. CrossrefGoogle Scholar9. MelbyEgdahlBossenmaierSpink JCRHICWW: Suppression by Cortisol of increased serum-transaminase induced by endotoxin, Lancet 1: 441-444, 1959. CrossrefMedlineGoogle Scholar10. KolarsSpink CPWW: Thrombopenic purpura as a complication of mumps, J. A. M. A. 168: 2213-2215, 1958. CrossrefMedlineGoogle Scholar11. Spink WW: The significance of bacterial hypersensitivity in human brucellosis: studies on infection due to strain 19 Brucella abortus , Ann. Int. Med. 47: 861-874, 1957. LinkGoogle Scholar12. AbernathySpink RSWW: Studies with brucella endotoxin in humans: the significance of susceptibility to endotoxin in the pathogenesis of brucellosis, J. Clin. Investigation 37: 219-231, 1958. CrossrefMedlineGoogle Scholar13. SpinkHall WWWH: The influence of cortisone and adrenocorticotrophic hormone on brucellosis. II. Adrenocorticotrophic hormone (ACTH) in acute and chronic human brucellosis, J. Clin. Investigation 31: 958-968, 1952. CrossrefMedlineGoogle Scholar14. Joint FAO/WHO Expert Committee on Brucellosis, Third Report, W.H.O. Technical Report Series No. 148, Geneva, 1958. Google Scholar15. RibbleBraude JCAI: ACTH and adrenal steroids in treatment of pneumococcal meningitis in adults, Am. J. Med. 24: 68-79, 1958. CrossrefMedlineGoogle Scholar16. SmadelLeyDiercks JEHLFH: Treatment of typhoid fever. I. Combined therapy with cortisone and chloramphenicol, Ann. Int. Med. 34: 1-9, 1951. LinkGoogle Scholar17. CareyHarveyHowardWagley RAAMJEPF: The effect of adrenocorticotrophic hormone (ACTH) and cortisone on drug hypersensitivity reactions, Bull. Johns Hopkins Hosp. 87: 354-414, 1950. MedlineGoogle Scholar18. RukesOrrForshamGalante JMRHPHM: The use of intravenous hydrocortisone in major surgery, Ann. New York Acad. Sc. 61: 448-459, 1955. CrossrefMedlineGoogle Scholar19. Connolly JE: The use of adrenal cortical compounds in hemorrhagic shock, Journal-Lancet 79: 460-463, 1959. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Minneapolis, Minnesota*Received for publication December 22, 1959.Presented at the Seventy-second Annual Meeting of the American Clinical and Climatological Association, Hot Springs, Va., Nov. 4, 1959.From the Department of Medicine, University of Minnesota Medical School, Minneapolis.Requests for reprints should be addressed to Wesley W. Spink, M.D., Department of Medicine, University of Minnesota Medical School, Minneapolis 14, Minnesota. 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REIMANN, M.D., F.A.C.P.Management of Bacterial Meningitis in Children 1 July 1960Volume 53, Issue 1Page: 1-32KeywordsAdrenocorticotropic hormoneHepatitis AInfectious diseasesInflammationMeningoencephalitisOral administrationOrchitisSteroid therapySteroidsTuberculosis ePublished: 1 December 2008 Issue Published: 1 July 1960 Copyright & PermissionsCopyright, ©, 1960, by The American College of PhysiciansPDF downloadLoading ...